The difficult calls in RNA editing
نویسندگان
چکیده
منابع مشابه
RNA Editing RNA
RNA Editing RNA editing is a term used to describe a diverse set of phenomena in which mRNA, rRNA, and tRNA transcripts are modified in sequence after transcription. The types of RNA editing vary from uridine (U) or cytidine (C) insertions and deletions within coding regions of mitochondrial mRNAs to the substitution of specific C residues with U residues in plant mitochondrial mRNAs or the sub...
متن کاملRNA editing.
RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum, (c) the C-to-U substitution editing of the ma...
متن کاملREDIdb: the RNA editing database
The RNA Editing Database (REDIdb) is an interactive, web-based database created and designed with the aim to allocate RNA editing events such as substitutions, insertions and deletions occurring in a wide range of organisms. The database contains both fully and partially sequenced DNA molecules for which editing information is available either by experimental inspection (in vitro) or by computa...
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RNA-seq data can be mined for sequence differences relative to the reference genome to identify both genomic SNPs and RNA editing events. We analyzed the long, polyA-selected, unstranded, deeply sequenced RNA-seq data from the ENCODE Project across 14 human cell lines for candidate RNA editing events. On average, 43% of the RNA sequencing variants that are not in dbSNP and are within gene bound...
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In vitro editing in mammalian nuclear extracts reveals adenosine-to-inosine conversions in glutamate receptor messenger RNAs.
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2012
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.2452